Sevoflurane: properties, pros and cons on human body


Sevoflurane is an inhalation anesthetic that is useful for general anesthesia.


  • Simple name:- C4H3F7O
  • Saturated Vapor Pressure:- 159 mmHg at 200C
  • Boiling Point:- 58.60C
  • Does not react to metals and the breathing circuit of the anesthesia machine
  • Colorless
  • Non-pungent smell
  • Non-flammable
  • Chemically stable at room temperature


  • Low toxicity
  • Low airway irritants in comparison to desflurane and isoflurane. So masks can be used by patients of all age groups.
  • Economical in comparison to desflurane
  • Low blood solubility
  • High potency (low MAC value)
  • Low metabolism (3 to 5%)


Common side effects include

  • Nausea:- 25%
  • Vomiting:- 18%
  • Hypotension:- 4% to 11%
  • Agitation:- 7% to 15%

An increase in the concentration of this anesthetic agent can also cause

  • A decrease in blood pressure and cardiac output
  • Apnea
  • Laryngospasm

Sevoflurane reaction with the CO2 absorber

  • Sevoflurane is quite unstable in soda-lime producing Compound A.  Experiments have shown that Compound A may be responsible for organ toxicity such as hepatic and renal. Thus avoid fresh gas flow (FGF) at 1 L/min for no more than 2 MAC-Hours (2 L/min FGF can be used indefinitely).
  • There is a chance of the formation of carbon monoxide with dry sevoflurane.

Monitoring parameters

Following parameters of the patient must be checked while using sevoflurane

  • Pulse rate
  • FiO2
  • FiCO2
  • SPO2, etc.


  • The blood gas partition coefficient is low (0.69).
  • A low partition ratio indicates that the agent is not much soluble in blood. Thus, the undissolved gas goes to the brain and diffuses quickly. Also, the recovery rate will be high.
  • 5% dose in adults and 7% dose in children will cause induction for surgical anesthesia within 2 minutes.

Storage of sevoflurane

You can find sevoflurane in an amber color bottle (250 ml). It has to be stored at a low temperature (150C to 250C) due to its high volatility.

Agent specific vaporizer for sevoflurane

  • Drager Vapor 2000 vaporizer is one of them

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