ICU

Desflurane: properties, pros and cons to human body

Desflurane

 Desflurane is an inhalation anesthetic that is widely used in the anesthesia machine.

Properties

  • Simple name:- C3H2F6O
  • Saturated Vapor Pressure:- 669 mmHg at 200C
  • Boiling Point:- 22.80C
  • Does not react to metals
  • Colorless
  • Pungent smell

Advantages

  • Non-toxic
  • Economical during long procedures
  • Does not show convulsive activity on EEG
  • Low blood solubility
  • High potency (low MAC value)
  • Low metabolism (0.02%)

Disadvantages

Common drawbacks include

  • Irritation to the patient
  • Poor analgesic property
  • Nausea
  • Vomiting
  • Cough
  • Breath-holding
  • Apnea
  • Costly than other inhalation anesthetics.

Monitoring parameters while using desflurane

  • Pulse
  • Body temperature
  • Cardiac Rhythm
  • SPO2

Time

  • The blood gas partition coefficient is 0.42.
  • The gas works within 1 to 2 mins of administration.

Storage

You can find (250 ml) of desflurane in an amber color bottle. Since the gas is highly volatile you need to store it at a low temperature.

Desflurane is an airway irritant

Desflurane, when used at a higher concentration, causes irritation to the respiratory tract due to its pungent smell. So, nowadays, it is hardly used for patients showing spontaneous breathing. In other words, it is mostly in use for patients who need mandatory breathing.

Why is desflurane heated prior to its use?

Desflurane boils at room temperature. Also, it has got a high saturation vapor pressure. When the drug is administered to the patient, the liquid desflurane quickly converts into a gaseous stage to compensate for the loss of gas. So, the latent heat of vaporization causes drop in the temperature of the liquid.

On using for a longer period of time, temperature decreases even more. This decreases the rate of vaporization and pressure. So, there will be fluctuation in the vaporization during long use. So, to compensate for the drop in the temperature of the anesthetic agent, it has to be heated.

TEC – 6 is a type of vaporizer that is specially designed to solve the above problem.

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